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KMID : 1007520220310131631
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Food Science and Biotechnology
2022 Volume.31 No. 13 p.1631 ~ p.1638
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A self-emulsifying omega-3 fatty acids delivery system for enhanced gastro-intestinal absorption in rats
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Kim Yu-Mi
Jang Gi-Hyun
Seok Chang-Hwan
Kim Bo-Hyeon
Bae Jung-Woo
Kim Bae-Hwan
Yoon Myeong-Sik
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Abstract
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Omega-3 fatty acids have many health benefits as they help to prevent and treat coronary artery disease, hypertension, diabetes mellitus, arthritis, and autoimmune disorders. Omega-3 fatty acids miscible in lecithin were found to spontaneously form microemulsions in water. The particle sizes of emulsions ranged from 300 to 800 nm and their morphologies were observed by optical microscopy. In vitro testing showed that the amounts of omega-3 fatty acids released by self-emulsifying delivery (SED) formulations containing lecithin, were higher than that released by a commercial formulation without lecithin. The Cmax values of docosahexaenoic acid (DHA) or eicosapentaenoic acid (EPA) were approximately 1.38?1.40-fold for the optimized SED formulation than for the control group (P?
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KEYWORD
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Omega-3 fatty acid, Self-emulsifying delivery (SED), Phospholipid, Lecithin, Bioavailability
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